The most significant diagnostic sign of trazodone neutropenia is a periodically appearing decrease in the number of blood granulocytes. In a febrile period, as a rule, agranulocytosis is observed for 3-4 days, then neutrophils are found in the blood, but in a reduced amount. Often during this period, an increase in the number of lymphocytes occurs.
After the end of the neutropenia phase, laboratory tests record transient monocytosis, eosinophilia. Then, before the start of the next cycle, all indicators are completely back to normal.
In 70% of patients, a decrease in granulocytes occurs after 21 days, and lasts from 3 to 10 days (the degree of impairment, as a rule, correlates with the duration of neutropenia). However, there are also shorter (14 days) and longer (28-30 days) "light intervals".
After an attack of fever, the patient's condition returns to normal, however, some patients experience complications due to the development of otitis media, abscess pneumonia, etc.
In some cases, the cyclic appearance of agranulocytosis is accompanied by a decrease in the number of red blood cells and platelets. Treatment of agranulocytosis in cyclic neutropenia consists primarily in the prevention of infectious complications. The appointment of granulocyte colony-stimulating factor (G-CSF) reduces the severity of granulocytopenia, but does not completely eliminate cyclic trazodone.
trazodone is relatively favorable, since with age, the clinical manifestations of agranulocytosis in cyclic neutropenia are significantly mitigated. Granulocytopenia and agranulocytosis of newborns with isoimmune conflict. Severe granulocytopenia, in some cases reaching the degree of agranulocytosis, also occurs in the so-called isoimmune neutropenia. This pathology is a kind of granulocytic equivalent of hemolytic anemia in newborns with Rh-conflict.
The mechanism of trazodone of agranulocytosis in isoimmune neutropenia is based on the formation by the maternal body of antibodies to the child's granulocytes, which have an antigenic composition obtained from the father. As a rule, anthe titers are directed against the granulocyte progenitor cells in the red bone marrow. A feature of agranulocytosis in isoimmune conflict is its transitory nature - the mother's antibodies are quickly washed out of the body, and the number of granulocytes in the baby's blood spontaneously normalizes. Full recovery usually occurs 12–20 weeks after birth.
Therefore, the therapeutic tactic is to combat infectious complications using standard antibiotic therapy. Agranulocytosis: what it is, types and symptoms, causes and treatment, consequences and predictions. And granulocytosis is an acute or chronic disease, which is accompanied by a sharp drop in the number of white blood cells-granulocytes: eosinophils, basophils and neutrophils. The result is a pronounced violation of the immune function.
Do not confuse the diagnosis with non-granulocytic cells. Agranulocytes are mainly lymphocytes, they are not involved in the process. But the number of monocytes decreases. Pathology is quite common. Mainly in women of the older age group. At the same time, the prevalence, according to statistics, is approximately 1 case per 1000 people. Plus or minus (information varies by source).
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In general, the pathological process is extremely aggressive. Without treatment, the mortality rate is almost 80%. There is evidence of even greater mortality. The development of the disorder is based on three possible pathogenetic factors.
That is, one that is due to the influence of poisons on the patient's body. During the course of the disorder, the normal production of precursor cells of leukocytes and large phagocytic structures is disrupted.
Several main ones can be attributed to negatively affecting substances: Cytostatics. Medicines are especially dangerous in terms of hematopoiesis, production and maturation of white blood cells. They are drugs for the treatment of cancerous tumors. Less commonly used to eliminate an overly active immune response, in pathologies such as rheumatoid arthritis.
Other trazodone. Acetylsalicylic acid, anti-inflammatory non-steroidal origin, Analgin and its substitutes based on sodium metamizole, some hormonal trazodone.